MiniMed 640G cuts hypoglycemia; mother delivers a 4,137 g boy

AI system

System: Medtronic MiniMed sensor-augmented pump / automated insulin delivery with predictive low glucose suspend (SmartGuard)
Model: Not assessed
Release: Exact release not established.
Application developer: Medtronic
Role: The pump predicted low glucose and suspended insulin delivery.
Configuration: The initial event involved a MiniMed 640G. A later report involved a MiniMed 780G.
Inputs and outputs: Not assessed
Autonomy: Not assessed
Workflow: A person with type 1 diabetes and frequent or unrecognized hypoglycemia uses a Medtronic pump with CGM and predictive low glucose suspend enabled. Sensor glucose is predicted to fall and the algorithm suspends basal insulin. Hypoglycemia frequency and variability fall and the clinical goal (pregnancy, restored awareness) is reached.
Human oversight: Not assessed
Relation to AI: The pump's predictive algorithm autonomously suspended insulin for about four hours a day. The authors link this to fewer hypoglycemic episodes and lower variability. Obstetric and diabetes care were delivered by clinicians. The causal link to carrying the pregnancy is inferred, not demonstrated.
AI contribution: The pump's predictive algorithm autonomously suspended insulin for about four hours a day. The authors link this to fewer hypoglycemic episodes and lower variability. Obstetric and diabetes care were delivered by clinicians. The causal link to carrying the pregnancy is inferred, not demonstrated.

Studies: Not assessed
Study design: Not assessed
Measurement: Not assessed
Setting and sample: Not assessed
Measures: hypoglycemic episodes fell from 2.1–2.5 to 1.4 per day
Comparison: her two earlier pregnancies on a MiniMed 620G sensor-augmented pump without predictive low glucose suspend
Results: Reference: Hypoglycemic episodes (/day) 2.5 and 2.1; time with AUC below 70 mg/dL 1.1% and 1.4%. Result: Hypoglycemic episodes (/day) 1.4; mean AUC < 70 mg/dL of 0.5%.
Additional value from AI: Not assessed
Limitations: Not assessed
Denominators: Not assessed
Materials for replication: Not assessed

Conditions for replication: Sensor is worn and calibrated with suspend enabled. The user does not override suspensions. Clinical follow-up adjusts settings.
Replication attempts: 1 follow-up entries. Benefit recurred: 1.
Later findings: No development for this patient after the 2021 case report was found; the 2025 MiniMed 780G report concerns a different patient.
Availability: Not assessed
Institutional decision: Not assessed
Grounds: Not assessed
Action and result: Not assessed
Success criterion: Not assessed

Assessed benefits: People.
Depth: People: 3.
Reasons: People: After two miscarriages, hypoglycemia frequency and glucose variability fell on the device and the pregnancy reached term with a healthy infant. A life-changing benefit, though the source does not prove the device caused the live birth.
Observed or intended: Not assessed
Rubric: Not assessed
Assessor and date: Not assessed
Alternative assessments: Not assessed
Fill: The deployer's account

Kind: Not assessed
Related entries: Not assessed
Field: Healthcare (diabetes; obstetrics). Diabetes technology.
Purpose: Predictive low glucose suspend is built to stop insulin delivery when sensor glucose is predicted to fall low, to avoid hypoglycemia. The benefit was that purpose, with a successful pregnancy as the downstream outcome.
Dates: Date basis unassessed: 2021 (precision unassessed). Updated: 21 October 2026.
Stage: Not assessed
Version: SHA-256: bc612c5c94bf…

Case report Deployer

Honoki H, Yagi K, Tsuda S, Wada T, Enkaku A, Nakagawa-Yokoyama M, Kamigishi M, Shikata M, Takikawa-Nishida A, Fujisaka S, Chujo D, Sasaoka T, Nakashima A, Saito S, Tobe K (2021). Type 1 diabetes woman with repeated miscarriages successfully gave birth after introducing an insulin pump with a predictive low glucose suspend feature. Diabetology International 12:324-329.
Case report Deployer

Honoki H et al. (2021). Diabetology International 12:324-329.
Case report Deployer

Zadáková E, Horová E (2025). Case Report: Hybrid closed-loop insulin pump can significantly improve awareness of hypoglycemia. Frontiers in Clinical Diabetes and Healthcare 6:1536038.