{"id":"AIBD-1162","title":"Singapore's ACE finds that EchoGo Heart Failure appeared safe and accurate and reclassified most cases that clinical scores left indeterminate","summary":"Singapore's ACE found that EchoGo Heart Failure appeared safe and accurate on retrospective data. It reclassified 73.5% of cases left indeterminate by the HFA-PEFF score.","date_observed":"2025-04-30","date_basis":"source publication","date_precision":"day","benefit_status":"mixed","source_collection":null,"source_entry":null,"account":"Ultromics built EchoGo Heart Failure, machine learning software that reads one routine echocardiogram clip. It gives a yes-or-no reading for heart failure with preserved ejection fraction (HFpEF). Singapore's Agency for Care Effectiveness (ACE) reviewed the evidence in a brief published on 30 April 2025. ACE drew on three retrospective case-control studies and one retrospective real-world study. One of the case-control studies was a conference abstract. Sensitivity ranged from 87.8% to 89.8% and specificity from 55.6% to 86.3%. In the main study, two clinical scores left 54.6% and 60.4% of cases non-diagnostic, against 7.3% for the software. It reclassified 73.5% of cases that the HFA-PEFF score left indeterminate. ACE wrote that it appears less accurate than traditional clinical scores and that it can reclassify the cases they leave indeterminate. ACE found limited data on clinical utility and no cost-effectiveness study. Most studies were supported by Ultromics grants or had authors employed by the company. ACE notes that its brief rests on a limited literature search and does not appraise the studies.","category":"aggregate result","unexpected":false,"purpose":"Ultromics built EchoGo Heart Failure to help clinicians detect heart failure with preserved ejection fraction from a single routine echocardiogram clip.","system":"EchoGo Heart Failure","model_version":null,"developer":"Ultromics Ltd.","deployer":"Hospitals in the retrospective US and UK studies that ACE reviewed (not yet in use in Singapore)","location":"United States and United Kingdom (studies), assessed for Singapore","domain":"Healthcare","segment":null,"benefit_type":"Improved Task Accuracy","work_activities":["4.A.1.b.1","4.A.2.a.4"],"taxonomy_note":null,"registry_ids":{},"ratings":[{"group":"organizational","depth":null,"reason":"ACE relied on retrospective studies in which the software guided no care, and it found limited data on clinical utility."}],"ai_role":{"status":"assessed","statement":"The main study set the software's results against two clinical scores, and its authors compared management decisions with and without the model. All the studies were retrospective, and most had funding or authors from Ultromics. ACE describes the software as a machine learning-based decision support system."},"evidence":[{"kind":"assessment report","citation":"Agency for Care Effectiveness (ACE), Ministry of Health, Singapore. EchoGo Heart Failure to Aid in the Diagnosis of Heart Failure with Preserved Ejection Fraction. ACE Brief for New and Emerging Health Technologies, HSB-M 01/2025, dated March 2025, published on 30 April 2025. Summary of Key Points, p. 2.","title":"EchoGo Heart Failure to Aid in the Diagnosis of Heart Failure with Preserved Ejection Fraction (HSB-M 01/2025)","url":"https://isomer-user-content.by.gov.sg/68/55e34a4a-9a64-4e9d-9fe9-dea47842f372/EchoGo%20Heart%20Failure%20to%20Aid%20in%20the%20Diagnosis%20of%20Heart%20Failure%20with%20Preserved%20Ejection%20Fraction.pdf","date":"2025-04-30","written_by":"independent","quote":"Based on three retrospective case-control studies (one of which is a conference abstract) and one retrospective real-world study, EchoGo Heart Failure appeared to be safe and accurate, with limited clinical utility data."},{"kind":"assessment report","citation":"Agency for Care Effectiveness (ACE), Ministry of Health, Singapore. EchoGo Heart Failure to Aid in the Diagnosis of Heart Failure with Preserved Ejection Fraction. ACE Brief for New and Emerging Health Technologies, HSB-M 01/2025, dated March 2025, published on 30 April 2025. Section VI, Summary of Evidence, Summary, p. 9.","title":"EchoGo Heart Failure to Aid in the Diagnosis of Heart Failure with Preserved Ejection Fraction (HSB-M 01/2025)","url":"https://isomer-user-content.by.gov.sg/68/55e34a4a-9a64-4e9d-9fe9-dea47842f372/EchoGo%20Heart%20Failure%20to%20Aid%20in%20the%20Diagnosis%20of%20Heart%20Failure%20with%20Preserved%20Ejection%20Fraction.pdf","date":"2025-04-30","written_by":"independent","quote":"Although it appears to be less accurate than traditional clinical scores, it can reclassify indeterminate cases resulting from them."}],"replication":{"produced_by":["The software read one apical four-chamber video clip from a routine transthoracic echocardiogram showing an ejection fraction of at least 50%.","It sent a binary HFpEF classification to the physician's workstation through a cloud server within 20 minutes."],"must_hold":["Patients are adults over 25 years suspected of heart failure, with an ejection fraction of at least 50%.","An interpreting clinician uses the result as an adjunct to standard diagnostic pathways.","Cloud processing of patient data must meet data protection rules, such as Singapore's Personal Data Protection Act."],"echoes":[]},"paired_incident":null,"headline":"*EchoGo Heart Failure* reclassified most cases that scores left open","metric":"reclassified 73.5% of cases left indeterminate by the HFA-PEFF score","comparator":{"against":"The HFA-PEFF and H2FPEF clinical scores in the main training and validation study","before":"54.6% and 60.4% non-diagnostic outcomes","after":"7.3% non-diagnostic outputs","basis":"measured","quote":"However, both algorithms had high proportions of non-diagnostic outcomes, 54.6% and 60.4%, respectively, compared to 7.3% in EchoGo HF testing data (see in Table 3).","url":"https://isomer-user-content.by.gov.sg/68/55e34a4a-9a64-4e9d-9fe9-dea47842f372/EchoGo%20Heart%20Failure%20to%20Aid%20in%20the%20Diagnosis%20of%20Heart%20Failure%20with%20Preserved%20Ejection%20Fraction.pdf"},"later":null,"value":null,"developer_country":"United Kingdom","deployer_country":"United States and United Kingdom","unrated_because":"The evidence came from retrospective studies with limited data on clinical utility, so no realized outcome is reported for any group.","brief_notes":null,"brief":null,"revisions":[{"date":"2026-11-01","change":"Added the record from the finding of Singapore's Agency for Care Effectiveness (ACE).","source":"https://isomer-user-content.by.gov.sg/68/55e34a4a-9a64-4e9d-9fe9-dea47842f372/EchoGo%20Heart%20Failure%20to%20Aid%20in%20the%20Diagnosis%20of%20Heart%20Failure%20with%20Preserved%20Ejection%20Fraction.pdf","editor":"AIBD"}],"confidence":"found","shade":"high","claim_status":"Found by an assessment body","claim_basis":"Sources: one independent assessment report. 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