{"id":"AIBD-1122","title":"NICE finds that HeartFlow FFRCT is safe and accurate and may spare patients invasive coronary angiography, with savings of £391 per patient","summary":"NICE found that HeartFlow FFRCT is safe and accurate. In one study, planned invasive angiography was canceled for 61% of patients, and NICE estimated savings of £391 per patient in 2021.","date_observed":"2021-05-19","date_basis":"source publication","date_precision":"day","benefit_status":"reported","source_collection":null,"source_entry":null,"account":"The National Institute for Health and Care Excellence (NICE) recommended HeartFlow FFRCT in February 2017 and updated its guidance on 19 May 2021. The software calculates fractional flow reserve, a measure of blood flow past a narrowed artery, from coronary CT angiography. NICE's committee relied on an external assessment center's review of the evidence. In the NXT trial, adding FFRCT to CT angiography raised specificity against invasive measurement. In the PLATFORM study, planned invasive angiography was canceled for 61% of patients in the FFRCT arm. Among patients with planned angiography, 12% in that arm had no obstructive disease at angiography, against 73% with functional imaging. NICE concluded that the test is safe and accurate and may avoid invasive investigations. With its 2021 cost model, NICE estimated savings of £391 per patient. Its committee judged that further studies would help clarify use in routine practice. 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