{ "id": "AIBD-0123", "title": "Wireless epidural BCI lets a man quadriplegic for 14 years drink unaided (NEO, Xuanwu Hospital and Tsinghua)", "summary": "54-year-old man, quadriplegic for 14 years, drank unaided by driving a pneumatic glove through the NEO epidural BCI; announced 29 January 2024.", "date_observed": "2024-01-29", "date_basis": "unassessed", "date_precision": "unassessed", "benefit_status": null, "source_collection": null, "source_entry": null, "account": "On 24 October 2023, teams led by Zhao Guoguang (Xuanwu Hospital) and Hong Bo (Tsinghua University) implanted the NEO wireless epidural brain-computer interface (BCI). The patient was a 54-year-old man with complete C4 spinal cord injury (ASIA A) from a car accident, quadriplegic for 14 years. Discharged ten days later, he trained three months at home. At a 29 January 2024 trial-phase summary meeting the team reported he could drive a pneumatic glove with his brain activity to drink water unaided. Grasp-decoding accuracy was above 90%, with improved ASIA scores and somatosensory evoked potentials. A September 2024 preprint reported nine months of home use: a 0.91 grasp-detection F1-score, eating and drinking, and a 27-point ARAT gain.", "category": "benefit created", "unexpected": false, "purpose": "NEO was built to let people with tetraplegia control external equipment, including a pneumatic exoskeleton glove, from epidural brain signals. The aim is assistance and hand-function rehabilitation at home. Restoring this patient's grasp so that he could drink was that purpose.", "system": "NEO (Neural Electronic Opportunity) wireless minimally invasive epidural brain-computer interface: eight epidural electrodes over the sensorimotor cortex, a battery-free coin-sized skull implant powered and read through the scalp, and a Riemannian-geometry grasp-intention decoder driving a pneumatic exoskeleton glove", "model_version": "NEO（Neural Electronic Opportunity）", "developer": "Tsinghua University School of Medicine, Prof. Hong Bo's team, with Neuracle Medical Technology (Shanghai) Co., Ltd. (博睿康科技), the trial sponsor", "deployer": "Xuanwu Hospital, Capital Medical University, Beijing (teams of Zhao Guoguang and Shan Yongzhi)", "location": "Beijing, China", "domain": "Healthcare", "segment": "Neurotechnology and spinal cord injury rehabilitation", "benefit_type": "Improved Physical Health", "taxonomy_note": "Drinking unaided through the pneumatic glove is also an accessibility gain.", "registry_ids": { "oecd_aim": "2024-01-27-c761" }, "ratings": [ { "group": "personal", "depth": 3, "reason": "After 14 years of complete quadriplegia the patient regained the ability to drink and eat by himself through the BCI-driven glove. The preprint reports neurological recovery: upper-limb motor score +5, ARAT +27, and the ability to hold objects without the BCI." } ], "ai_role": { "status": "assessed", "statement": "The AI contribution is the decoder, a Riemannian-geometry classifier with a hidden Markov model for temporal smoothing. Calibrated in about ten minutes on beta, low-gamma and high-gamma features of eight-channel epidural ECoG, it detects grasp intention and triggers the pneumatic glove. The preprint reports 94% calibration accuracy and a grasp-detection F1-score rising above 0.9 after three months (average 0.91 over nine months). It gives 100% object-transfer success with the BCI against 35% without. The electrodes, implant, surgery and glove are not AI. The authors attribute the later neurological recovery to repeated BCI training, not the decoder alone." }, "evidence": [ { "kind": "preprint", "citation": "Liu D, Shan Y, Wei P, Li W, Xu H, Liang F, Liu T, Zhao G, Hong B (2024). Reclaiming Hand Functions after Complete Spinal Cord Injury with Epidural Brain-Computer Interface. medRxiv 2024.09.05.24313041 (v1 6 Sep 2024; v7 15 Jul 2025).", "title": "Reclaiming Hand Functions after Complete Spinal Cord Injury with Epidural Brain-Computer Interface", "url": "https://doi.org/10.1101/2024.09.05.24313041", "date": "2024-09-06", "written_by": "makers", "quote": "Over a 9-month period of home use, the patient achieved an average grasping detection F1-score of 0.91, and a 100% success rate in object transfer tests" }, { "kind": "news report", "citation": "Chen Bin, China Science Daily / ScienceNet (2024). 首例患者脑机接口康复取得突破性进展 [First patient's brain-computer interface rehabilitation makes breakthrough progress]. news.sciencenet.cn, 31 January 2024.", "title": "首例患者脑机接口康复取得突破性进展", "url": "https://news.sciencenet.cn/htmlnews/2024/1/516951.shtm", "date": "2024-01-31", "written_by": "independent", "quote": "患者可以通过脑电活动驱动气动手套，实现自主喝水等脑控功能，抓握解码准确率超过90%" }, { "kind": "news report", "citation": "Interface News (界面新闻), republished by CCTV News (2024). 我国脑机接口实现技术突破，四肢截瘫患者实现脑控喝水 [China's BCI achieves technical breakthrough; quadriplegic patient drinks by brain control]. news.cctv.com, 31 January 2024.", "title": "我国脑机接口实现技术突破，四肢截瘫患者实现脑控喝水", "url": "https://news.cctv.com/2024/01/31/ARTIAm1lfoEPddPWL8sZzJPd240131.shtml", "date": "2024-01-31", "written_by": "independent", "quote": "54岁，男性，此前长期处于四肢瘫痪状态" }, { "kind": "news report", "citation": "Sun Leqi, Beijing Daily client (2024). 脑机接口技术重大突破，让四肢截瘫患者实现自主脑控喝水 [Major BCI breakthrough lets quadriplegic patient drink by brain control]. news.bjd.com.cn, 31 January 2024.", "title": "脑机接口技术重大突破，让四肢截瘫患者实现自主脑控喝水", "url": "https://news.bjd.com.cn/2024/01/31/10691652.shtml", "date": "2024-01-31", "written_by": "independent", "quote": "去年10月24日，宣武医院院长赵国光团队和清华大学教授洪波团队共同完成了无线微创脑机接口NEO临床植入试验" }, { "kind": "regulatory document", "citation": "Neuracle Medical Technology (Shanghai) Co., Ltd. (2023, updated 2024). A Prospective Clinical Trial to Evaluate the Safety and Efficacy of an Implantable Neural Acquisitor & Stimulator System in Patients With Motor Disability. ClinicalTrials.gov NCT05920174.", "title": "Clinical Trial to Evaluate the Safety and Efficacy of an Implantable Neural Acquisitor & Stimulator System in Patients With Motor Disability", "url": "https://clinicaltrials.gov/study/NCT05920174", "date": "2023-06-27", "written_by": "makers", "quote": "patients can control the external equipment（wheelchairs, robotic arms, the WeChat app and other physical aids）with brain signals to improve the patients quality of life" }, { "kind": "news report", "citation": "People's Daily client, republished on Tsinghua University's 'Media Tsinghua' page (2024). 中国脑机接口技术新进展！截瘫患者实现\"脑控喝水\" [New progress in China's BCI technology: paraplegic patient achieves 'brain-controlled drinking']. tsinghua.edu.cn, page dated 6 February 2024.", "title": "中国脑机接口技术新进展！截瘫患者实现\"脑控喝水\"", "url": "https://www.tsinghua.edu.cn/info/1182/109663.htm", "date": "2024-02-06", "written_by": "independent", "quote": "在1月29日召开的临床试验阶段总结会上，联合团队宣布首例患者脑机接口康复取得突破性进展" } ], "replication": { "produced_by": [ "Eight chronic epidural electrodes over the sensorimotor cortex of a patient whose cortex still generated grasp-related signals after 14 years of complete C4 injury", "A grasp-intention decoder calibrated in about ten minutes and robust to the signal drift and chewing artifacts of home use", "A battery-free implant powered and read through the scalp, so the patient could train at home daily after discharge ten days post-surgery", "A wearable pneumatic glove able to execute the decoded grasp on the patient's right hand, which retained limited forearm movement" ], "must_hold": [ "The patient's motor cortex must still produce decodable grasp intention despite years of paralysis", "The decoder must stay accurate without frequent recalibration across months of home use", "The patient or a caregiver must be able to attach the external coil and the glove for daily sessions", "Neurological recovery beyond assisted grasping is a single-patient finding and must be reproduced in further patients" ], "echoes": [] }, "paired_incident": null, "headline": "NEO BCI lets a man quadriplegic for 14 years drink unaided", "metric": "drink water unaided, with grasp-decoding accuracy above 90%", "comparator": { "against": "his own state before implantation, quadriplegic for 14 years after complete cervical spinal cord injury (ASIA A)", "before": "处于四肢瘫痪状态已经14年 (no hand function for 14 years)", "after": "实现自主喝水等脑控功能，抓握解码准确率超过90% (brain-controlled drinking, grasp decoding accuracy above 90%)", "basis": "measured", "quote": "经过三个月的居家脑机接口康复训练，患者可以通过脑电活动驱动气动手套，实现自主喝水等脑控功能，抓握解码准确率超过90%；患者脊髓损伤的ASIA临床评分和感觉诱发电位响应均有显著改善。", "url": "https://news.sciencenet.cn/htmlnews/2024/1/516951.shtm" }, "later": { "status": "unknown", "date": null, "note": "Later work includes a September 2024 medRxiv preprint on nine months of home use and a Tsinghua Medicine page on a 2025 multicenter trial. Their findings remain unverified.", "quote": null, "url": null }, "value": null, "developer_country": "China", "deployer_country": "China", "unrated_because": null, "brief_notes": null, "brief": null, "revisions": [ { "date": "2026-10-20", "change": "Record drafted from the OECD Monitor entry and the cited sources.", "source": "https://oecd.ai/en/incidents/2024-01-27-c761", "editor": "AIBD" }, { "date": "2026-10-21", "change": "Benefit type set to Improved Physical Health under Trustible's full taxonomy of 23 types; it was Improved Accessibility among the six first used.", "source": "https://trustible.ai/post/a-framework-for-measuring-the-benefits-of-ai/", "editor": "AIBD" }, { "date": "2026-10-21", "change": "Added what the benefit is measured against, the model version from the cited sources.", "source": "https://news.sciencenet.cn/htmlnews/2024/1/516951.shtm; https://news.sciencenet.cn/htmlnews/2024/1/516951.shtm", "editor": "AIBD" }, { "date": "2026-10-21", "change": "Country of the developer added from the organization's own site or a registry.", "source": "https://en.wikipedia.org/wiki/Tsinghua_University", "editor": "AIBD" }, { "date": "2026-10-21", "change": "Country of the deployer added from the organization's own site or a registry.", "source": "https://en.wikipedia.org/wiki/Xuanwu_Hospital", "editor": "AIBD" }, { "date": "2026-10-21", "change": "Prose pass: a rating reason, account, purpose, the system's part rewritten in shorter sentences with abbreviations expanded; facts, figures and quotations unchanged.", "source": null, "editor": "AIBD" } ], "confidence": "reported", "shade": "medium", "claim_status": "Independently reported", "claim_basis": "Sources: four independent news reports, the makers' regulatory document and the makers' preprint. The cited evidence includes no independent study or report and no finding by a regulator or court.", "profile": { "case_id": "AIBD-0123", "catalog_version": "1.0.0", "source_fingerprint": "fbb504178db47e2724955bf5311c462d14b4b2b6a308f9541240335cdb8e4d4b", "collection_refs": [ { "collection_id": "aibd", "version": "snapshot-8bf7cfec9cb185aa" }, { "collection_id": "aibd", "version": "2026-10-25" } ], "source_ids": [ "AIBD-0123-source-0001", "AIBD-0123-source-0002", "AIBD-0123-source-0003", "AIBD-0123-source-0004", "AIBD-0123-source-0005", "AIBD-0123-source-0006" ], "families": { "strategic assessments": { "state": "not_assessed", "review_state": "not_assessed", "coverage": "partial", "record_ids": [] }, "evaluations": { "state": "not_assessed", "review_state": "not_assessed", "coverage": "partial", "record_ids": [] }, "monetary observations": { "state": "not_assessed", "review_state": "not_assessed", "coverage": "partial", "record_ids": [] }, "institutional decisions": { "state": "not_assessed", "review_state": "not_assessed", "coverage": "partial", "record_ids": [] } }, "fields": { "actors[]": { "state": "value_present", "value": { "kind": "record_fields", "fields": { "developer": "Tsinghua University School of Medicine, Prof. Hong Bo's team, with Neuracle Medical Technology (Shanghai) Co., Ltd. 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Their findings remain unverified." } } }, "provenance": { "kind": "legacy_record", "basis": "Preserved from the existing AIBD record; external sources were not rechecked.", "record_fields": [ "later" ], "source_refs": [] }, "review_state": "record_mapped", "coverage": "partial" }, "human_oversight": { "state": "not_assessed", "review_state": "not_assessed", "coverage": "partial" }, "id": { "state": "value_present", "value": { "kind": "record_fields", "fields": { "id": "AIBD-0123" } }, "provenance": { "kind": "legacy_record", "basis": "Preserved from the existing AIBD record; external sources were not rechecked.", "record_fields": [ "id" ], "source_refs": [] }, "review_state": "record_mapped", "coverage": "partial" }, "infrastructure_dependencies[]": { "state": "not_assessed", "review_state": "not_assessed", "coverage": "partial" }, "outcomes[].beneficiaries": { "state": "not_assessed", "review_state": "not_assessed", "coverage": "partial" }, "outcomes[].beneficiary_count": { "state": "not_assessed", "review_state": "not_assessed", "coverage": "partial" }, "outcomes[].benefit_type": { "state": "value_present", "value": { "kind": "record_fields", "fields": { "benefit_type": "Improved Physical Health", "taxonomy_note": "Drinking unaided through the pneumatic glove is also an accessibility gain." } }, "provenance": { "kind": "legacy_record", "basis": "Preserved from the existing AIBD record; external sources were not rechecked.", "record_fields": [ "benefit_type", "taxonomy_note" ], "source_refs": [] }, "review_state": "record_mapped", "coverage": "partial" }, "outcomes[].claim": { "state": "value_present", "value": { "kind": "record_fields", "fields": { "account": "On 24 October 2023, teams led by Zhao Guoguang (Xuanwu Hospital) and Hong Bo (Tsinghua University) implanted the NEO wireless epidural brain-computer interface (BCI). The patient was a 54-year-old man with complete C4 spinal cord injury (ASIA A) from a car accident, quadriplegic for 14 years. Discharged ten days later, he trained three months at home. At a 29 January 2024 trial-phase summary meeting the team reported he could drive a pneumatic glove with his brain activity to drink water unaided. Grasp-decoding accuracy was above 90%, with improved ASIA scores and somatosensory evoked potentials. A September 2024 preprint reported nine months of home use: a 0.91 grasp-detection F1-score, eating and drinking, and a 27-point ARAT gain.", "benefit_type": "Improved Physical Health" } }, "provenance": { "kind": "legacy_record", "basis": "Preserved from the existing AIBD record; external sources were not rechecked.", "record_fields": [ "account", "benefit_type" ], "source_refs": [] }, "review_state": "record_mapped", "coverage": "partial" }, "outcomes[].distribution": { "state": "not_assessed", "review_state": "not_assessed", "coverage": "partial" }, "outcomes[].duration": { "state": "not_assessed", "review_state": "not_assessed", "coverage": "partial" }, "outcomes[].id": { "state": "not_assessed", "review_state": "not_assessed", "coverage": "partial" }, "outcomes[].stakeholder_group": { "state": "value_present", "value": { "kind": "record_fields", "fields": { "ratings": [ { "group": "personal", "depth": 3, "reason": "After 14 years of complete quadriplegia the patient regained the ability to drink and eat by himself through the BCI-driven glove. The preprint reports neurological recovery: upper-limb motor score +5, ARAT +27, and the ability to hold objects without the BCI." } ] } }, "provenance": { "kind": "legacy_record", "basis": "Preserved from the existing AIBD record; external sources were not rechecked.", "record_fields": [ "ratings" ], "source_refs": [] }, "review_state": "record_mapped", "coverage": "partial" }, "outcomes[].status": { "state": "not_assessed", "review_state": "not_assessed", "coverage": "partial" }, "outcomes[].tradeoffs": { "state": "not_assessed", "review_state": "not_assessed", "coverage": "partial" }, "outcomes[].unexpected": { "state": "value_present", "value": { "kind": "record_fields", "fields": { "unexpected": false, "purpose": "NEO was built to let people with tetraplegia control external equipment, including a pneumatic exoskeleton glove, from epidural brain signals. The aim is assistance and hand-function rehabilitation at home. Restoring this patient's grasp so that he could drink was that purpose." } }, "provenance": { "kind": "legacy_record", "basis": "Preserved from the existing AIBD record; external sources were not rechecked.", "record_fields": [ "unexpected", "purpose" ], "source_refs": [] }, "review_state": "record_mapped", "coverage": "partial" }, "places[]": { "state": "value_present", "value": { "kind": "record_fields", "fields": { "location": "Beijing, China", "developer_country": "China", "deployer_country": "China" } }, "provenance": { "kind": "legacy_record", "basis": "Preserved from the existing AIBD record; external sources were not rechecked.", "record_fields": [ "location", "developer_country", "deployer_country" ], "source_refs": [] }, "review_state": "record_mapped", "coverage": "partial" }, "purpose": { "state": "value_present", "value": { "kind": "record_fields", "fields": { "purpose": "NEO was built to let people with tetraplegia control external equipment, including a pneumatic exoskeleton glove, from epidural brain signals. The aim is assistance and hand-function rehabilitation at home. Restoring this patient's grasp so that he could drink was that purpose." } }, "provenance": { "kind": "legacy_record", "basis": "Preserved from the existing AIBD record; external sources were not rechecked.", "record_fields": [ "purpose" ], "source_refs": [] }, "review_state": "record_mapped", "coverage": "partial" }, "record_dates": { "state": "value_present", "value": { "kind": "record_fields", "fields": { "date_observed": "2024-01-29", "revisions": [ { "date": "2026-10-20", "change": "Record drafted from the OECD Monitor entry and the cited sources.", "source": "https://oecd.ai/en/incidents/2024-01-27-c761", "editor": "AIBD" }, { "date": "2026-10-21", "change": "Benefit type set to Improved Physical Health under Trustible's full taxonomy of 23 types; it was Improved Accessibility among the six first used.", "source": "https://trustible.ai/post/a-framework-for-measuring-the-benefits-of-ai/", "editor": "AIBD" }, { "date": "2026-10-21", "change": "Added what the benefit is measured against, the model version from the cited sources.", "source": "https://news.sciencenet.cn/htmlnews/2024/1/516951.shtm; https://news.sciencenet.cn/htmlnews/2024/1/516951.shtm", "editor": "AIBD" }, { "date": "2026-10-21", "change": "Country of the developer added from the organization's own site or a registry.", "source": "https://en.wikipedia.org/wiki/Tsinghua_University", "editor": "AIBD" }, { "date": "2026-10-21", "change": "Country of the deployer added from the organization's own site or a registry.", "source": "https://en.wikipedia.org/wiki/Xuanwu_Hospital", "editor": "AIBD" }, { "date": "2026-10-21", "change": "Prose pass: a rating reason, account, purpose, the system's part rewritten in shorter sentences with abbreviations expanded; facts, figures and quotations unchanged.", "editor": "AIBD" } ] } }, "provenance": { "kind": "legacy_record", "basis": "Preserved from the existing AIBD record; external sources were not rechecked.", "record_fields": [ "date_observed", "revisions" ], "source_refs": [] }, "review_state": "record_mapped", "coverage": "partial" }, "replication.attempts[]": { "state": "not_assessed", "review_state": "not_assessed", "coverage": "partial" }, "replication.conditions": { "state": "value_present", "value": { "kind": "record_fields", "fields": { "replication": { "produced_by": [ "Eight chronic epidural electrodes over the sensorimotor cortex of a patient whose cortex still generated grasp-related signals after 14 years of complete C4 injury", "A grasp-intention decoder calibrated in about ten minutes and robust to the signal drift and chewing artifacts of home use", "A battery-free implant powered and read through the scalp, so the patient could train at home daily after discharge ten days post-surgery", "A wearable pneumatic glove able to execute the decoded grasp on the patient's right hand, which retained limited forearm movement" ], "must_hold": [ "The patient's motor cortex must still produce decodable grasp intention despite years of paralysis", "The decoder must stay accurate without frequent recalibration across months of home use", "The patient or a caregiver must be able to attach the external coil and the glove for daily sessions", "Neurological recovery beyond assisted grasping is a single-patient finding and must be reproduced in further patients" ], "echoes": [] } } }, "provenance": { "kind": "legacy_record", "basis": "Preserved from the existing AIBD record; external sources were not rechecked.", "record_fields": [ "replication" ], "source_refs": [] }, "review_state": "record_mapped", "coverage": "partial" }, "revision_history[]": { "state": "value_present", "value": { "kind": "record_fields", "fields": { "revisions": [ { "date": "2026-10-20", "change": "Record drafted from the OECD Monitor entry and the cited sources.", "source": "https://oecd.ai/en/incidents/2024-01-27-c761", "editor": "AIBD" }, { "date": "2026-10-21", "change": "Benefit type set to Improved Physical Health under Trustible's full taxonomy of 23 types; it was Improved Accessibility among the six first used.", "source": "https://trustible.ai/post/a-framework-for-measuring-the-benefits-of-ai/", "editor": "AIBD" }, { "date": "2026-10-21", "change": "Added what the benefit is measured against, the model version from the cited sources.", "source": "https://news.sciencenet.cn/htmlnews/2024/1/516951.shtm; https://news.sciencenet.cn/htmlnews/2024/1/516951.shtm", "editor": "AIBD" }, { "date": "2026-10-21", "change": "Country of the developer added from the organization's own site or a registry.", "source": "https://en.wikipedia.org/wiki/Tsinghua_University", "editor": "AIBD" }, { "date": "2026-10-21", "change": "Country of the deployer added from the organization's own site or a registry.", "source": "https://en.wikipedia.org/wiki/Xuanwu_Hospital", "editor": "AIBD" }, { "date": "2026-10-21", "change": "Prose pass: a rating reason, account, purpose, the system's part rewritten in shorter sentences with abbreviations expanded; facts, figures and quotations unchanged.", "editor": "AIBD" } ] } }, "provenance": { "kind": "legacy_record", "basis": "Preserved from the existing AIBD record; external sources were not rechecked.", "record_fields": [ "revisions" ], "source_refs": [] }, "review_state": "record_mapped", "coverage": "partial" }, "sector": { "state": "value_present", "value": { "kind": "record_fields", "fields": { "domain": "Healthcare", "segment": "Neurotechnology and spinal cord injury rehabilitation" } }, "provenance": { "kind": "legacy_record", "basis": "Preserved from the existing AIBD record; external sources were not rechecked.", "record_fields": [ "domain", "segment" ], "source_refs": [] }, "review_state": "record_mapped", "coverage": "partial" }, "sources[].access_version": { "state": "not_assessed", "review_state": "not_assessed", "coverage": "partial" }, "sources[].citation_locator": { "state": "value_present", "value": { "kind": "record_fields", "fields": { "evidence": [ { "kind": "preprint", "citation": "Liu D, Shan Y, Wei P, Li W, Xu H, Liang F, Liu T, Zhao G, Hong B (2024). Reclaiming Hand Functions after Complete Spinal Cord Injury with Epidural Brain-Computer Interface. medRxiv 2024.09.05.24313041 (v1 6 Sep 2024; v7 15 Jul 2025).", "title": "Reclaiming Hand Functions after Complete Spinal Cord Injury with Epidural Brain-Computer Interface", "url": "https://doi.org/10.1101/2024.09.05.24313041", "date": "2024-09-06", "written_by": "makers", "quote": "Over a 9-month period of home use, the patient achieved an average grasping detection F1-score of 0.91, and a 100% success rate in object transfer tests" }, { "kind": "news report", "citation": "Chen Bin, China Science Daily / ScienceNet (2024). 首例患者脑机接口康复取得突破性进展 [First patient's brain-computer interface rehabilitation makes breakthrough progress]. news.sciencenet.cn, 31 January 2024.", "title": "首例患者脑机接口康复取得突破性进展", "url": "https://news.sciencenet.cn/htmlnews/2024/1/516951.shtm", "date": "2024-01-31", "written_by": "independent", "quote": "患者可以通过脑电活动驱动气动手套，实现自主喝水等脑控功能，抓握解码准确率超过90%" }, { "kind": "news report", "citation": "Interface News (界面新闻), republished by CCTV News (2024). 我国脑机接口实现技术突破，四肢截瘫患者实现脑控喝水 [China's BCI achieves technical breakthrough; quadriplegic patient drinks by brain control]. news.cctv.com, 31 January 2024.", "title": "我国脑机接口实现技术突破，四肢截瘫患者实现脑控喝水", "url": "https://news.cctv.com/2024/01/31/ARTIAm1lfoEPddPWL8sZzJPd240131.shtml", "date": "2024-01-31", "written_by": "independent", "quote": "54岁，男性，此前长期处于四肢瘫痪状态" }, { "kind": "news report", "citation": "Sun Leqi, Beijing Daily client (2024). 脑机接口技术重大突破，让四肢截瘫患者实现自主脑控喝水 [Major BCI breakthrough lets quadriplegic patient drink by brain control]. news.bjd.com.cn, 31 January 2024.", "title": "脑机接口技术重大突破，让四肢截瘫患者实现自主脑控喝水", "url": "https://news.bjd.com.cn/2024/01/31/10691652.shtml", "date": "2024-01-31", "written_by": "independent", "quote": "去年10月24日，宣武医院院长赵国光团队和清华大学教授洪波团队共同完成了无线微创脑机接口NEO临床植入试验" }, { "kind": "regulatory document", "citation": "Neuracle Medical Technology (Shanghai) Co., Ltd. (2023, updated 2024). A Prospective Clinical Trial to Evaluate the Safety and Efficacy of an Implantable Neural Acquisitor & Stimulator System in Patients With Motor Disability. ClinicalTrials.gov NCT05920174.", "title": "Clinical Trial to Evaluate the Safety and Efficacy of an Implantable Neural Acquisitor & Stimulator System in Patients With Motor Disability", "url": "https://clinicaltrials.gov/study/NCT05920174", "date": "2023-06-27", "written_by": "makers", "quote": "patients can control the external equipment（wheelchairs, robotic arms, the WeChat app and other physical aids）with brain signals to improve the patients quality of life" }, { "kind": "news report", "citation": "People's Daily client, republished on Tsinghua University's 'Media Tsinghua' page (2024). 中国脑机接口技术新进展！截瘫患者实现\"脑控喝水\" [New progress in China's BCI technology: paraplegic patient achieves 'brain-controlled drinking']. tsinghua.edu.cn, page dated 6 February 2024.", "title": "中国脑机接口技术新进展！截瘫患者实现\"脑控喝水\"", "url": "https://www.tsinghua.edu.cn/info/1182/109663.htm", "date": "2024-02-06", "written_by": "independent", "quote": "在1月29日召开的临床试验阶段总结会上，联合团队宣布首例患者脑机接口康复取得突破性进展" } ] } }, "provenance": { "kind": "legacy_record", "basis": "Preserved from the existing AIBD record; external sources were not rechecked.", "record_fields": [ "evidence" ], "source_refs": [] }, "review_state": "record_mapped", "coverage": "partial" }, "sources[].id": { "state": "value_present", "value": { "kind": "identifiers", "identifiers": [ "AIBD-0123-source-0001", "AIBD-0123-source-0002", "AIBD-0123-source-0003", "AIBD-0123-source-0004", "AIBD-0123-source-0005", "AIBD-0123-source-0006" ], "role": "Existing evidence items, in their original order" }, "provenance": { "kind": "curatorial", "basis": "Stable within the fingerprinted record version; no source content or source review has been added.", "record_fields": [], "source_refs": [] }, "review_state": "record_mapped", "coverage": "complete" }, "sources[].language": { "state": "not_assessed", "review_state": "not_assessed", "coverage": "partial" }, "sources[].relationship": { "state": "value_present", "value": { "kind": "record_fields", "fields": { "evidence": [ { "kind": "preprint", "citation": "Liu D, Shan Y, Wei P, Li W, Xu H, Liang F, Liu T, Zhao G, Hong B (2024). Reclaiming Hand Functions after Complete Spinal Cord Injury with Epidural Brain-Computer Interface. medRxiv 2024.09.05.24313041 (v1 6 Sep 2024; v7 15 Jul 2025).", "title": "Reclaiming Hand Functions after Complete Spinal Cord Injury with Epidural Brain-Computer Interface", "url": "https://doi.org/10.1101/2024.09.05.24313041", "date": "2024-09-06", "written_by": "makers", "quote": "Over a 9-month period of home use, the patient achieved an average grasping detection F1-score of 0.91, and a 100% success rate in object transfer tests" }, { "kind": "news report", "citation": "Chen Bin, China Science Daily / ScienceNet (2024). 首例患者脑机接口康复取得突破性进展 [First patient's brain-computer interface rehabilitation makes breakthrough progress]. news.sciencenet.cn, 31 January 2024.", "title": "首例患者脑机接口康复取得突破性进展", "url": "https://news.sciencenet.cn/htmlnews/2024/1/516951.shtm", "date": "2024-01-31", "written_by": "independent", "quote": "患者可以通过脑电活动驱动气动手套，实现自主喝水等脑控功能，抓握解码准确率超过90%" }, { "kind": "news report", "citation": "Interface News (界面新闻), republished by CCTV News (2024). 我国脑机接口实现技术突破，四肢截瘫患者实现脑控喝水 [China's BCI achieves technical breakthrough; quadriplegic patient drinks by brain control]. news.cctv.com, 31 January 2024.", "title": "我国脑机接口实现技术突破，四肢截瘫患者实现脑控喝水", "url": "https://news.cctv.com/2024/01/31/ARTIAm1lfoEPddPWL8sZzJPd240131.shtml", "date": "2024-01-31", "written_by": "independent", "quote": "54岁，男性，此前长期处于四肢瘫痪状态" }, { "kind": "news report", "citation": "Sun Leqi, Beijing Daily client (2024). 脑机接口技术重大突破，让四肢截瘫患者实现自主脑控喝水 [Major BCI breakthrough lets quadriplegic patient drink by brain control]. news.bjd.com.cn, 31 January 2024.", "title": "脑机接口技术重大突破，让四肢截瘫患者实现自主脑控喝水", "url": "https://news.bjd.com.cn/2024/01/31/10691652.shtml", "date": "2024-01-31", "written_by": "independent", "quote": "去年10月24日，宣武医院院长赵国光团队和清华大学教授洪波团队共同完成了无线微创脑机接口NEO临床植入试验" }, { "kind": "regulatory document", "citation": "Neuracle Medical Technology (Shanghai) Co., Ltd. (2023, updated 2024). A Prospective Clinical Trial to Evaluate the Safety and Efficacy of an Implantable Neural Acquisitor & Stimulator System in Patients With Motor Disability. ClinicalTrials.gov NCT05920174.", "title": "Clinical Trial to Evaluate the Safety and Efficacy of an Implantable Neural Acquisitor & Stimulator System in Patients With Motor Disability", "url": "https://clinicaltrials.gov/study/NCT05920174", "date": "2023-06-27", "written_by": "makers", "quote": "patients can control the external equipment（wheelchairs, robotic arms, the WeChat app and other physical aids）with brain signals to improve the patients quality of life" }, { "kind": "news report", "citation": "People's Daily client, republished on Tsinghua University's 'Media Tsinghua' page (2024). 中国脑机接口技术新进展！截瘫患者实现\"脑控喝水\" [New progress in China's BCI technology: paraplegic patient achieves 'brain-controlled drinking']. tsinghua.edu.cn, page dated 6 February 2024.", "title": "中国脑机接口技术新进展！截瘫患者实现\"脑控喝水\"", "url": "https://www.tsinghua.edu.cn/info/1182/109663.htm", "date": "2024-02-06", "written_by": "independent", "quote": "在1月29日召开的临床试验阶段总结会上，联合团队宣布首例患者脑机接口康复取得突破性进展" } ] } }, "provenance": { "kind": "legacy_record", "basis": "Preserved from the existing AIBD record; external sources were not rechecked.", "record_fields": [ "evidence" ], "source_refs": [] }, "review_state": "record_mapped", "coverage": "partial" }, "sources[].upstream_sources": { "state": "not_assessed", "review_state": "not_assessed", "coverage": "partial" }, "strategic_assessments[]": { "state": "not_assessed", "review_state": "not_assessed", "coverage": "partial", "family": "strategic assessments" }, "summary": { "state": "value_present", "value": { "kind": "record_fields", "fields": { "summary": "54-year-old man, quadriplegic for 14 years, drank unaided by driving a pneumatic glove through the NEO epidural BCI; announced 29 January 2024.", "account": "On 24 October 2023, teams led by Zhao Guoguang (Xuanwu Hospital) and Hong Bo (Tsinghua University) implanted the NEO wireless epidural brain-computer interface (BCI). The patient was a 54-year-old man with complete C4 spinal cord injury (ASIA A) from a car accident, quadriplegic for 14 years. Discharged ten days later, he trained three months at home. At a 29 January 2024 trial-phase summary meeting the team reported he could drive a pneumatic glove with his brain activity to drink water unaided. Grasp-decoding accuracy was above 90%, with improved ASIA scores and somatosensory evoked potentials. A September 2024 preprint reported nine months of home use: a 0.91 grasp-detection F1-score, eating and drinking, and a 27-point ARAT gain." } }, "provenance": { "kind": "legacy_record", "basis": "Preserved from the existing AIBD record; external sources were not rechecked.", "record_fields": [ "summary", "account" ], "source_refs": [] }, "review_state": "record_mapped", "coverage": "partial" }, "systems[].autonomy_permissions": { "state": "not_assessed", "review_state": "not_assessed", "coverage": "partial" }, "systems[].component_role": { "state": "value_present", "value": { "kind": "text", "text": "The decoder detected intended grasping movements and triggered the pneumatic glove." }, "provenance": { "kind": "legacy_record", "basis": "Restated the mechanical task already described in the existing system and AI-role fields. No new source review is claimed.", "record_fields": [ "system", "ai_role" ], "source_refs": [] }, "review_state": "record_mapped", "coverage": "partial" }, "systems[].deployment_configuration": { "state": "value_present", "value": { "kind": "text", "text": "The deployment used the NEO brain-computer interface." }, "provenance": { "kind": "legacy_record", "basis": "Separated the model, software, hardware, or operation already described in the existing record. No new source review is claimed.", "record_fields": [ "model_version", "system", "ai_role" ], "source_refs": [] }, "review_state": "record_mapped", "coverage": "partial" }, "systems[].inputs_outputs": { "state": "not_assessed", "review_state": "not_assessed", "coverage": "partial" }, "systems[].model_name": { "state": "value_present", "value": { "kind": "text", "text": "A classifier based on Riemannian geometry, with a hidden Markov model for temporal smoothing." }, "provenance": { "kind": "legacy_record", "basis": "Separated the model, software, hardware, or operation already described in the existing record. No new source review is claimed.", "record_fields": [ "model_version", "system", "ai_role" ], "source_refs": [] }, "review_state": "record_mapped", "coverage": "partial" }, "systems[].model_version": { "state": "value_present", "value": { "kind": "record_fields", "fields": { "model_version": "NEO（Neural Electronic Opportunity）" } }, "provenance": { "kind": "legacy_record", "basis": "Preserved from the existing AIBD record; external sources were not rechecked.", "record_fields": [ "model_version" ], "source_refs": [] }, "review_state": "record_mapped", "coverage": "partial", "display": { "answer": "Exact release not established.", "editor_note": "" } }, "systems[].product_name": { "state": "value_present", "value": { "kind": "record_fields", "fields": { "system": "NEO (Neural Electronic Opportunity) wireless minimally invasive epidural brain-computer interface: eight epidural electrodes over the sensorimotor cortex, a battery-free coin-sized skull implant powered and read through the scalp, and a Riemannian-geometry grasp-intention decoder driving a pneumatic exoskeleton glove" } }, "provenance": { "kind": "legacy_record", "basis": "Preserved from the existing AIBD record; external sources were not rechecked.", "record_fields": [ "system" ], "source_refs": [] }, "review_state": "record_mapped", "coverage": "partial" }, "systems[].provider": { "state": "value_present", "value": { "kind": "structured", "data": { "application_developer": "Tsinghua University School of Medicine, Prof. Hong Bo's team, with Neuracle Medical Technology (Shanghai) Co., Ltd. (博睿康科技), the trial sponsor" } }, "provenance": { "kind": "legacy_record", "basis": "Mapped from the existing case description without a new external source review.", "record_fields": [ "developer" ], "source_refs": [] }, "review_state": "record_mapped", "coverage": "partial" }, "taxonomy_crosswalks[]": { "state": "not_assessed", "review_state": "not_assessed", "coverage": "partial" }, "title": { "state": "value_present", "value": { "kind": "record_fields", "fields": { "title": "Wireless epidural BCI lets a man quadriplegic for 14 years drink unaided (NEO, Xuanwu Hospital and Tsinghua)", "headline": "NEO BCI lets a man quadriplegic for 14 years drink unaided" } }, "provenance": { "kind": "legacy_record", "basis": "Preserved from the existing AIBD record; external sources were not rechecked.", "record_fields": [ "title", "headline" ], "source_refs": [] }, "review_state": "record_mapped", "coverage": "partial" }, "version": { "state": "value_present", "value": { "kind": "identifiers", "identifiers": [ "fbb504178db47e2724955bf5311c462d14b4b2b6a308f9541240335cdb8e4d4b" ], "role": "SHA-256 of normalized original case data" }, "provenance": { "kind": "curatorial", "basis": "Deterministic content version assigned by the local migration.", "record_fields": [], "source_refs": [] }, "review_state": "record_mapped", "coverage": "complete" }, "workflow": { "state": "value_present", "value": { "kind": "record_fields", "fields": { "account": "On 24 October 2023, teams led by Zhao Guoguang (Xuanwu Hospital) and Hong Bo (Tsinghua University) implanted the NEO wireless epidural brain-computer interface (BCI). The patient was a 54-year-old man with complete C4 spinal cord injury (ASIA A) from a car accident, quadriplegic for 14 years. Discharged ten days later, he trained three months at home. At a 29 January 2024 trial-phase summary meeting the team reported he could drive a pneumatic glove with his brain activity to drink water unaided. Grasp-decoding accuracy was above 90%, with improved ASIA scores and somatosensory evoked potentials. A September 2024 preprint reported nine months of home use: a 0.91 grasp-detection F1-score, eating and drinking, and a 27-point ARAT gain.", "replication": { "produced_by": [ "Eight chronic epidural electrodes over the sensorimotor cortex of a patient whose cortex still generated grasp-related signals after 14 years of complete C4 injury", "A grasp-intention decoder calibrated in about ten minutes and robust to the signal drift and chewing artifacts of home use", "A battery-free implant powered and read through the scalp, so the patient could train at home daily after discharge ten days post-surgery", "A wearable pneumatic glove able to execute the decoded grasp on the patient's right hand, which retained limited forearm movement" ], "must_hold": [ "The patient's motor cortex must still produce decodable grasp intention despite years of paralysis", "The decoder must stay accurate without frequent recalibration across months of home use", "The patient or a caregiver must be able to attach the external coil and the glove for daily sessions", "Neurological recovery beyond assisted grasping is a single-patient finding and must be reproduced in further patients" ], "echoes": [] } } }, "provenance": { "kind": "legacy_record", "basis": "Preserved from the existing AIBD record; external sources were not rechecked.", "record_fields": [ "account", "replication" ], "source_refs": [] }, "review_state": "record_mapped", "coverage": "partial" } }, "summary": { "total": 91, "addressed": 91, "known": 33, "reviewed": 0, "record_mapped": 33, "not_assessed": 58, "complete": false, "by_state": { "value_present": 33, "not_reported": 0, "unresolved": 0, "not_assessed": 58, "not_applicable": 0, "withheld": 0, "source_unavailable": 0 } } } }